Peer-reviewed veterinary case report
Horse has a tongue tumor - what does it mean?
By Seeliger, F et al.·Published in Veterinary pathology·2007·Department of Pathology, Germany·View original on PubMed →
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Original publication title: Confocal laser scanning analysis of an equine oral mast cell tumor with atypical expression of tyrosine kinase receptor C-KIT.
- Species:
- horse
Plain-English summary
A 20-year-old female horse had a firm, ulcerated growth on the side of her tongue, which was diagnosed as a mast cell tumor. This type of tumor is made up of certain immune cells and was found to have some unusual characteristics under a microscope. Fortunately, the tumor was not linked to a poor prognosis, meaning the horse is expected to do well despite the diagnosis.
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Abstract
A 20-year-old female horse showed a nodular, firm, focal ulcerated mast cell tumor at the right dorsobuccal face of the tongue. Histologically, the nonencapsulated tumor consisted of dense, infiltrating aggregates of well-differentiated, Cresyl violet-positive mast cells accompanied by numerous eosinophils. Furthermore, they exhibited a strong, diffuse, intracytoplasmatic immunohistochemical signal for tryptase and a faint membrane-associated and perinuclear signal for tyrosine kinase receptor KIT. Confocal laser scanning microscopy confirmed an aberrant spatial colocalization of KIT in the Golgi apparatus, which may be the result of a defective protein processing within the tumor cells. The tumor was not associated with a poor prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17317803/