Peer-reviewed veterinary case report
Confocal laser scanning analysis of an equine oral mast cell tumor with atypical expression of tyrosine kinase receptor C-KIT.
- Journal:
- Veterinary pathology
- Year:
- 2007
- Authors:
- Seeliger, F et al.
- Affiliation:
- Department of Pathology · Germany
- Species:
- horse
Plain-English summary
A 20-year-old female horse had a firm, nodular tumor on the side of her tongue that was ulcerated. The tumor was made up of a type of immune cell called mast cells, which were found in large numbers along with other cells that help with inflammation. Tests showed that the tumor cells had unusual patterns of a specific protein that usually helps regulate cell growth, suggesting there might be a problem with how the cells are processing this protein. Fortunately, the tumor is not linked to a poor outlook for the horse's health.
Abstract
A 20-year-old female horse showed a nodular, firm, focal ulcerated mast cell tumor at the right dorsobuccal face of the tongue. Histologically, the nonencapsulated tumor consisted of dense, infiltrating aggregates of well-differentiated, Cresyl violet-positive mast cells accompanied by numerous eosinophils. Furthermore, they exhibited a strong, diffuse, intracytoplasmatic immunohistochemical signal for tryptase and a faint membrane-associated and perinuclear signal for tyrosine kinase receptor KIT. Confocal laser scanning microscopy confirmed an aberrant spatial colocalization of KIT in the Golgi apparatus, which may be the result of a defective protein processing within the tumor cells. The tumor was not associated with a poor prognosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17317803/