Peer-reviewed veterinary case report
Congenital heart outflow defects in dogs and how they run in families
By Ontiveros, Eric S et al.·Published in Frontiers in veterinary science·2019·Department of Medicine and Epidemiology, United States·View original on PubMed →
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Original publication title: Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017.
- Species:
- dog
Plain-English summary
A study found that subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are common congenital heart problems in dogs, particularly affecting breeds like Bullmastiffs and Bulldogs. SAS was diagnosed in about 0.3% of all hospital admissions, while PS was found in 0.41%. The research suggests that these conditions may be inherited in an autosomal recessive manner, meaning both parents need to carry the gene for their puppies to be affected. This information can help breeders make better choices to reduce the chances of these heart issues in future litters.
People also search for: dog heart problems · Bullmastiff congenital heart disease · Bulldog heart disease inheritance
Abstract
Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3% of overall hospital admissions and 4.7% for all dogs seen by the cardiology service. The prevalence for PS was 0.41% of overall hospital admissions and 6.1% of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59 and 4.46%, respectively) and odds ratio (52.43 and 34.73, respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8 and 2.7%, respectively) and odds ratio (13.32 and 7.52, respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30873420/