Peer-reviewed veterinary case report
Male Labrador retriever littermates with rare blood and muscle
By Thomas-Hollands, Alison et al.·Published in Journal of veterinary internal medicine·2021·Department of Clinical Sciences and Advanced Medicine, United States·View original on PubMed →
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Original publication title: Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates.
- Species:
- dog
Plain-English summary
Two male Labrador retriever littermates were found to have unusual blood and muscle issues. One dog showed signs of muscle wasting and had specific findings in a muscle biopsy. Tests, including bone marrow aspiration and an echocardiogram, confirmed that they had a rare condition called congenital dyserythropoiesis (a blood production issue) and congenital polymyopathy (muscle weakness), but they did not have heart problems. Recognizing these conditions early can help avoid unnecessary tests or even euthanasia, as the overall health impact seems to be low.
People also search for: Labrador retriever muscle weakness · dog blood disorder symptoms · congenital dyserythropoiesis in dogs
Abstract
BACKGROUND: Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a rare clinical entity of suspected congenital dyserythropoiesis and polymyopathy. Clinicopathologic changes were similar to a previously reported syndrome of congenital dyserythropoiesis, congenital polymyopathy, and cardiac disease in 3 related English Springer Spaniel (ESS) dogs, but the dogs reported here did not have apparent cardiac disease. INTERVENTIONS: Bone marrow aspiration, electromyography, muscle biopsies, and an echocardiogram were performed on dog 1. Results supported dyserythropoiesis and congenital polymyopathy similar to reports in ESS dogs, but did not identify obvious cardiac disease. CONCLUSION: The clinicopathologic changes of dyserythropoiesis and polymyopathy provide an easily recognizable phenotype for what appears to be a low morbidity syndrome. Early recognition may decrease unnecessary testing or euthanasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34227150/