Peer-reviewed veterinary case report
Cat with congenital corneal swelling linked to growth hormone
By Donaldson, D et al.·Published in The Journal of small animal practice·2008·Comparative Ophthalmology Unit·View original on PubMed →
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Original publication title: Congenital hyposomatotropism in a domestic shorthair cat presenting with congenital corneal oedema.
- Species:
- cat
Plain-English summary
A six-month-old female domestic shorthair cat was brought to the vet because she wasn't growing properly and had cloudy eyes due to corneal swelling. The vet found that she had a rare condition called congenital hyposomatotropism, which affects growth hormone levels, and possibly hypothyroidism, which can also impact growth. Unfortunately, the cat passed away during testing, and further examination revealed severe damage to her eye cells, which contributed to her eye problems.
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Abstract
A six-month-old, female, domestic shorthair cat was presented with a history of failure to grow and bilateral corneal opacity caused by corneal oedema. Congenital hyposomatotropism and possible secondary hypothyroidism were diagnosed on the basis of fasting serum levels of insulin-like growth factor-1 and thyroxine levels, respectively. These endocrinopathies are rare in the cat and have not been reported to cause ocular signs. The cat died during investigation of these diseases, and histopathological examination of the eyes showed significantly reduced corneal endothelial cell density and number of corneal epithelial cell layers when compared with age-matched healthy control corneas. These changes were implicated in the development of the corneal oedema.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18422507/