Peer-reviewed veterinary case report
Two cats with congenital hypothyroidism caused by faulty thyroid
By Sjollema, B E et al.·Published in Acta endocrinologica·1991·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Congenital hypothyroidism in two cats due to defective organification: data suggesting loosely anchored thyroperoxidase.
- Species:
- cat
Plain-English summary
Two cats were diagnosed with congenital hypothyroidism, a condition where the thyroid gland doesn't produce enough hormones. One cat had a complete defect in processing iodide, while the other had a partial defect. Tests showed that the enzyme needed for this process was not properly anchored, leading to lower hormone production. Treatment details were not specified, but addressing the underlying issue could help manage their condition.
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Abstract
Two cats with congenital hypothyroidism are described. In vivo discharge of accumulated labelled iodide by perchlorate administration revealed defective organification of iodide, which was complete in one cat and partial in the other. In the cat with the partial organification defect, thyroid tissue was obtained for biochemical studies. No membrane-bound peroxidase activity could be demonstrated. The activity was found in the 100,000 x g supernatant. It is suggested that the loose enzyme anchoring caused decreased availability of peroxidase and as a consequence reduced capacity for organic binding of trapped iodide.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1659766/