Peer-reviewed veterinary case report
Congenital ichthyosis causing gray scaling in Great Dane puppies
By Hoffmann, A et al.·Published in Veterinary pathology·2016·Department of Pathology, Germany·View original on PubMed →
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Original publication title: Congenital Ichthyosis in 14 Great Dane Puppies With a New Presentation.
- Species:
- dog
Plain-English summary
Fourteen Great Dane puppies were found to have a skin condition that caused gray to yellow scaling and wrinkling on their heads and legs. This condition is a type of congenital ichthyosis, which means their skin was not developing normally from birth. A thorough examination of their skin revealed specific changes in the skin cells and hair follicles. Unfortunately, the study does not mention any treatments or outcomes for these puppies, so it's unclear how they were managed or if they improved.
People also search for: Great Dane puppy skin problems · congenital ichthyosis in dogs · puppy skin scaling treatment
Abstract
The present study describes a generalized congenital skin condition in 14 Great Dane puppies. Macroscopically, all dogs showed generalized gray to yellow scaling and skin wrinkles on the head and all 4 extremities. Skin sections were histologically examined using hematoxylin and eosin, Heidenhain's Azan, and Sudan red III staining methods and by conducting the alcian blue/periodic acid Schiff (AB/PAS) reaction technique on sections. Furthermore, incubation with hyaluronidase was performed. Skin samples were ultrastructurally analyzed using transmission electron microscopy. All affected Great Dane puppies had epidermal and follicular orthokeratotic hyperkeratosis, enlarged keratohyaline granules, vacuolated keratinocytes, and accumulations of an eosinophilic and alcianophilic, lipid-rich material within dilated hair follicular lumina and the cytoplasm of sebocytes. The macroscopic, histopathologic, and ultrastructural skin changes in all 14 Great Dane puppies indicate a new variant of a primary disorder of cornification with congenital, non-epidermolytic, lamellar ichthyosiform appearance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26242581/