Peer-reviewed veterinary case report
Signs and inheritance of dry eye and skin disease in Cavalier King
By Hartley, Claudia et al.·Published in Veterinary ophthalmology·2012·Unit of Comparative Ophthalmology, United Kingdom·View original on PubMed →
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Original publication title: Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs. Part I: clinical signs, histopathology, and inheritance.
- Species:
- dog
Plain-English summary
A group of Cavalier King Charles Spaniel dogs showed signs of congenital keratoconjunctivitis sicca (a condition causing dry eyes) and skin problems from a young age. These dogs had rough, curly coats, persistent scaling on their skin, and issues with their footpads and nails. Over time, treatments aimed at stimulating tear production didn't significantly improve tear production tests, but they seemed to slow down the worsening of eye symptoms. The condition appears to be inherited, meaning it can run in families.
People also search for: Cavalier King Charles Spaniel dry eyes treatment · dog skin problems rough coat · congenital keratoconjunctivitis sicca symptoms
Abstract
The clinical presentation and progression (over 9 months to 13 years) of congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID) in the Cavalier King Charles spaniel dog are described for six new cases and six previously described cases. Cases presented with a congenitally abnormal (rough/curly) coat and signs of KCS from eyelid opening. Persistent scale along the dorsal spine and flanks with a harsh frizzy and alopecic coat was evident in the first few months of life. Ventral abdominal skin was hyperpigmented and hyperkeratinized in adulthood. Footpads were hyperkeratinized from young adulthood with nail growth abnormalities and intermittent sloughing. Long-term follow-up of cases (13/25) is described. Immunomodulatory/lacrimostimulant treatment had no statistically significant effect on Schirmer tear test results, although subjectively, this treatment reduced progression of the keratitis. Histopathological analysis of samples (skin/footpads/lacrimal glands/salivary glands) for three new cases was consistent with an ichthyosiform dermatosis, with no pathology of the salivary or lacrimal glands identified histologically. Pedigree analysis suggests the syndrome is inherited by an autosomal recessive mode.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22212237/