Peer-reviewed veterinary case report
Congenital myasthenia gravis in Miniature Smooth Haired Dachshund
By Dickinson, Peter J et al.·Published in Journal of veterinary internal medicine·2005·Department of Surgical and Radiological Sciences, United States·View original on PubMed →
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Original publication title: Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs.
- Species:
- dog
Plain-English summary
Three 8-week-old Smooth-Haired Miniature Dachshund puppies were brought in with weakness and difficulty moving, which led to a diagnosis of congenital myasthenia gravis, a condition affecting muscle strength. The diagnosis was confirmed through tests and a positive response to a medication called edrophonium chloride. Interestingly, unlike most cases, the puppies showed improvement and their symptoms resolved on their own by the time they were 6 months old.
People also search for: Miniature Dachshund weakness · puppy myasthenia gravis treatment · congenital myasthenia gravis in dogs
Abstract
Three 8-week-old Miniature Smooth Haired Dachshund littermates were diagnosed with myasthenia gravis based on clinical signs, results of electrophysiological testing, and response to the short-acting anticholinesterase drug, edrophonium chloride. Congenital myasthenia gravis was confirmed by the demonstration of decreased acetylcholine-receptor density in external intercostal muscle in the absence of demonstrable serum antiacetylcholine receptor antibody or antibodies complexed to acetylcholine receptors in muscle biopsy samples. Unlike most previously reported cases of congenital myasthenia gravis that are relentlessly progressive, clinical signs resolved spontaneously by 6 months of age.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16355692/