Peer-reviewed veterinary case report
Horse with congenital blood cell issue - what does it mean?
By Gill, Amy F et al.·Published in Veterinary clinical pathology·2006·Department of Pathobiological Sciences, United States·View original on PubMed →
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Original publication title: Congenital Pelger-Huët anomaly in a horse.
- Species:
- horse
Plain-English summary
A 1.5-year-old male Arabian horse was brought to the vet with a serious open wound on his side. Blood tests showed an unusual number of immature white blood cells, which indicated a specific blood condition called Pelger-Huët anomaly (PHA). This condition affects how the horse's immune system functions, as it leads to improperly formed white blood cells. After ruling out other causes and confirming similar findings in the horse's father and siblings, the diagnosis was made. This case is notable as it is the first documented instance of congenital PHA in horses.
People also search for: horse open wound treatment · Arabian horse blood condition · Pelger-Huët anomaly in horses
Abstract
A 1.5-year-old male Arabian horse was referred to the Louisiana State University Veterinary Teaching Hospital and Clinic for an open deep laceration involving two thirds of the right trunk. The initial CBC results included an inflammatory leukogram, characterized by a marked degenerative left shift consisting of only immature band neutrophils (7500/microL, reference interval 0-100/microL) with toxic changes and no segmented neutrophils (0/microL, reference interval 2700-6700/microL). On abdominal ultrasonography, free abdominal fluid was found and collected for analysis. Abdominal fluid had a marked increase in total nucleated cells (40,600 cells/microL) consisting of 74% nondegenerate neutrophils that all were hyposegmented, with mature condensed chromatin. Re-evaluation of neutrophil morphology on the initial blood smear confirmed hyposegmentation and mature condensed chromatin, similar to that observed in cells in the abdominal fluid. A diagnosis of Pelger-Huët anomaly (PHA) was made in this colt. Congenital PHA was documented on the basis of persistent neutrophil hyposegmentation on serial blood smears, ruling out of acquired causes of PHA, and findings of similar neutrophil hyposegmentation on blood smears from the colt's sire and the sire's siblings. To our knowledge, this is the first reported case of congenital PHA in a horse.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17123255/