Contrast-Enhanced Computed Tomography Imaging Features of Primary Hepatic Neuroendocrine Carcinoma in a 4-Year-Old French Bulldog.

Abstract

A 4-year-old female-spayed French bulldog presented with symptoms of anorexia, lethargy and vomiting. Abdominal ultrasonography revealed multiple coalescing hyperechoic nodules in the liver. Single-phase contrast-enhanced computed tomography (CT) scan showed heterogeneous liver lobes with hyperattenuating parenchyma and multiple hypoattenuating lesions in the post-contrast phase. No other primary neoplastic lesions were observed. Laparoscopic liver biopsy, histopathology and immunohistochemistry confirmed primary hepatic neuroendocrine carcinoma (PHNEC). Consequently, in cases where multiple hyperechoic nodules on ultrasound and hypoattenuating nodules on post-contrast CT are observed in the liver, PHNEC should be considered as a differential diagnosis.