Peer-reviewed veterinary case report
Contribution of front-line, standard-of-care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2025
- Authors:
- Peroutka-Bigus, Nathan et al.
- Affiliation:
- Department of Microbiology · United States
Abstract
By assessing the standard-of-care regimen for tuberculosis (TB) in BALB/c and C3HeB/FeJ mice, we demonstrate that rifampin, with or without pyrazinamide, is essential for an effective bactericidal response and suppression of resistance. Potency measurements in anlipid-rich model and a rabbit caseum assay recapitulate the significance of rifampin as a sterilizing agent. These outcomes align with clinical performance, thus emphasizing the value ofpredictive tools and murine TB models with human-like pathology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40135920/