Peer-reviewed veterinary case report
Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2019
- Authors:
- Rodgers, Aoife M et al.
- Affiliation:
- School of Pharmacy · United Kingdom
- Species:
- rodent
Abstract
Using a murine model ofbacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could controlinfection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on thedelivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30858214/