Peer-reviewed veterinary case report
Control of viral rebound through therapeutic immunization with DermaVir.
- Journal:
- AIDS (London, England)
- Year:
- 2005
- Authors:
- Lisziewicz, Julianna et al.
- Affiliation:
- Research Institute for Genetic and Human Therapy · United States
Abstract
OBJECTIVE: To reconstitute immune responses capable of eliminating infected cells and suppressing viral load during chronic retroviral infection. DESIGN: : A topical, DNA-based therapeutic immunization (DermaVir) was designed to express most of the regulatory and structural viral genes in dendritic cells. METHODS: DermaVir alone and in combination with antiretroviral drugs was tested in chronically SIV-infected macaques. RESULTS: DermaVir provided virological, immunological and clinical benefit for SIV-infected macaques during chronic infection and AIDS. In combination with antiretroviral drugs, DermaVir augmented SIV-specific T-cell responses and enhanced control of viral load rebound during treatment interruptions. CONCLUSIONS: The results indicate the feasibility of therapeutic immunization even in immune compromised hosts, and suggest that DermaVir can complement antiretroviral drugs to sustain suppression of HIV-1 replication.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15627031/