Peer-reviewed veterinary case report
Stem cell hip injections improve limb function in dogs
By Vilar, Jose M et al.·Published in BMC veterinary research·2013·Department of Animal Pathology, Spain·View original on PubMed →
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Original publication title: Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.
- Species:
- dog
Plain-English summary
Eight dogs with severe hip osteoarthritis (OA) were treated with injections of their own fat-derived stem cells to see if it would help their limping. After 180 days, the dogs showed significant improvement in their ability to bear weight on the affected leg, indicating less pain and better mobility. This treatment helped reduce their lameness and improved their overall limb function.
People also search for: dog limping treatment · stem cell therapy for dogs arthritis · hip osteoarthritis in dogs
Abstract
BACKGROUND: Adipose-derived mesenchymal stem cell (ADMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with AD-MSC.The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA. RESULTS: Eight lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved after treatment of the OA groups, reaching 53.02% and 14.84% of body weight, respectively, at day 180, compared with only 43.56% and 12.16% at day 0. CONCLUSION: This study objectively demonstrated that intraarticular ADMSC therapy resulted in reduced lameness due to OA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23819757/