Peer-reviewed veterinary case report
Hairless dog's skin tumors shrank with heat and isotretinoin treatment
By Levine, N et al.·Published in Journal of the American Academy of Dermatology·1990·University of Arizona Health Sciences Center·View original on PubMed →
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Original publication title: Controlled localized heating and isotretinoin effects in canine squamous cell carcinoma.
- Species:
- dog
Plain-English summary
A hairless dog with multiple skin tumors caused by sun damage was treated with a combination of localized heating and isotretinoin, a medication often used for skin issues. The treatment led to the complete regression of four smaller tumors, while two larger tumors showed some improvement but did not fully clear. The combination of heat and isotretinoin may have worked together to help the dog's immune system fight the tumors. Overall, the dog responded well to the treatment, with significant improvement in its skin condition.
People also search for: dog skin tumors treatment · isotretinoin for dogs · squamous cell carcinoma in dogs
Abstract
Controlled localized radiofrequency heating and systemic isotretinoin were used serially as therapy in a hairless dog that developed multiple cutaneous squamous cell carcinomas in chronically sun-damaged skin. During the course of therapy, four superficial tumors regressed completely, both clinically and histologically. Two larger, deeper tumors showed clinical signs of regression but histologic clearing did not occur. Both treatment modalities are known to have antitumor effects independently and may exert their effects in an additive fashion. However, it is also possible that heat-induced injury to tumor cells could lead to retinoid-mediated enhancement of an immunologic response to tumor antigens or some other process that might lead to regression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2365879/