Peer-reviewed veterinary case report
Dog developed corneal plaque after levofloxacin eye drops
By Park, Young-Woo et al.·Published in Veterinary ophthalmology·2015·Daegu Animal Medical Center, South Korea·View original on PubMed →
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Original publication title: Corneal plaque containing levofloxacin in a dog.
- Species:
- dog
Plain-English summary
A 13-year-old male Yorkshire terrier developed a corneal ulcer in his right eye two weeks after surgery to remove a cataract. The vet treated the ulcer with levofloxacin eye drops, but this led to the formation of a white plaque on the cornea. The plaque was surgically removed, and the dog was switched to tobramycin eye drops for further treatment. Fortunately, the corneal ulcer healed completely two weeks after the surgery, and the dog was back to normal.
People also search for: dog corneal ulcer treatment · Yorkshire terrier eye problems · levofloxacin eye drops side effects
Abstract
A 13-year-old castrated male Yorkshire terrier developed a corneal ulcer 2 weeks after intracapsular lens extraction (ICLE) in the right eye. The corneal ulcer was treated with levofloxacin eye drops. A plaque with a white luster developed in the central cornea 2 weeks after treatment with levofloxacin eye drops. The corneal plaque was surgically removed under inhalant anesthesia. The corneal plaque displayed antimicrobial activity against Escherichia coli. Furthermore, levofloxacin content in the plaque was confirmed by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS). The corneal ulcer completely resolved 2 weeks after the surgical removal of the corneal lesion and replacement of levofloxacin eye drops with tobramycin eye drops. Although the topical use of levofloxacin is unlikely to lead to corneal chemical deposits due to the high water solubility of the drug compared to other topical fluoroquinolones, this patient developed corneal plaque of the antibiotic drop.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25707461/