Peer-reviewed veterinary case report
NT-proBNP and lipase levels linked to heart disease severity in dogs
By Park, Jun Seok et al.·Published in Journal of veterinary science·2019·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Correlation between NT-proBNP and lipase levels according to the severity of chronic mitral valve disease in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with chronic mitral valve disease (CMVD), a common heart condition, had their heart health and pancreatic enzyme levels monitored over time. The study found that as the severity of heart disease increased, levels of NT-proBNP (a marker for heart strain) also rose significantly, while lipase (an enzyme related to the pancreas) showed a smaller increase. This suggests that dogs with worsening heart disease may also experience changes in pancreatic function. Regular monitoring of these values can help veterinarians assess the progression of heart disease in dogs.
People also search for: dog heart disease symptoms · NT-proBNP levels in dogs · chronic mitral valve disease treatment
Abstract
Chronic mitral valve disease (CMVD) is the most common cardiovascular disease in dogs, causing decreased cardiac output that results in poor tissue perfusion and tissue damage to kidneys, pancreas, and other organs. The purpose of this study was to evaluate the relationships between heart disease severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) and lipase in dogs with CMVD, as well as to evaluate longitudinal changes in these values. A total of 84 dogs participated in this 2015 to 2017 study. Serum values of NT-proBNP and lipase were analyzed; radiography was used to measure the vertebral heart score and assess various echocardiographic values. NT-proBNP showed a strong positive correlation with increasing stage of heart disease; lipase showed a mild positive correlation with heart disease stage. When the three values (NT-proBNP, lipase and month) were continuously measured at 6-month intervals, all showed a correlation with the increasing length of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31364327/