Peer-reviewed veterinary case report
Diagnosing and treating granulomatous colitis in a dog
By Sims, Cory S. et al.·Published in Veterinary Clinical Pathology·2021·Department of Population Health and Pathobiology North Carolina State University College of Veterinary Medicine Raleigh NC USA, United States·View original on Crossref →
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Original publication title: Correlation of cytology to histology in a case of canine granulomatous colitis in a Boxer dog
- Species:
- dog
Plain-English summary
A 2-year-old mixed breed dog was brought in for chronic diarrhea with blood in the stool and weight loss. Tests on a rectal scraping showed signs of infection, leading to a diagnosis of granulomatous colitis, which is an inflammation of the colon often caused by bacteria. The dog was treated with an antibiotic called enrofloxacin, and within six weeks, the diarrhea and weight loss improved significantly. This case highlights how important it is to analyze both cytology (cell samples) and histology (tissue samples) for diagnosing this condition.
People also search for: dog chronic diarrhea treatment · Boxer dog blood in stool · granulomatous colitis in dogs · enrofloxacin for dog diarrhea
Abstract
AbstractA 2‐year‐old castrated male mixed breed dog presented to the North Carolina State Veterinary Teaching Hospital for chronic diarrhea with hematochezia and weight loss. Cytology performed on a rectal scraping revealed macrophages containing magenta, light pink, and variably blue granular inclusions, and phagocytosed material concerning for infectious organisms. Histopathology was consistent with granulomatous colitis and identified intra‐histiocytic bacterial organisms, confirmed by fluorescent in situ hybridization (FISH)—tissue culture‐confirmed Escherichia coli. Based on these findings, a diagnosis of granulomatous colitis was made. The patient was successfully treated with oral enrofloxacin, and near‐complete remission of signs was achieved within 6 weeks. This report describes a case of granulomatous colitis in a mixed breed dog, and is the first published description of the cytologic features of this uncommon disease, offering a valuable cytologic‐histologic correlation. In this case, the cytology was helpful in identifying features consistent with granulomatous colitis and prioritizing the differential diagnoses and diagnostic plan.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.13058