Peer-reviewed veterinary case report
Dog with granulomatous colitis diagnosed by cytology and biopsy
By Sims, Cory S et al.·Published in Veterinary clinical pathology·2022·Department of Population Health and Pathobiology, United States·View original on PubMed →
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Original publication title: Correlation of cytology to histology in a case of canine granulomatous colitis in a Boxer dog.
- Species:
- dog
Plain-English summary
A 2-year-old mixed breed dog was brought to the vet for chronic diarrhea, blood in the stool, and weight loss. Tests showed signs of granulomatous colitis, a type of intestinal inflammation often linked to a bacterial infection. The vet treated the dog with an antibiotic called enrofloxacin, and within six weeks, the dog's symptoms improved significantly. This case highlights how important it is to analyze both cytology (cell samples) and histology (tissue samples) to diagnose this condition accurately.
People also search for: dog chronic diarrhea treatment · Boxer dog weight loss · granulomatous colitis in dogs · enrofloxacin for dogs · dog blood in stool causes
Abstract
A 2-year-old castrated male mixed breed dog presented to the North Carolina State Veterinary Teaching Hospital for chronic diarrhea with hematochezia and weight loss. Cytology performed on a rectal scraping revealed macrophages containing magenta, light pink, and variably blue granular inclusions, and phagocytosed material concerning for infectious organisms. Histopathology was consistent with granulomatous colitis and identified intra-histiocytic bacterial organisms, confirmed by fluorescent in situ hybridization (FISH)-tissue culture-confirmed Escherichia coli. Based on these findings, a diagnosis of granulomatous colitis was made. The patient was successfully treated with oral enrofloxacin, and near-complete remission of signs was achieved within 6 weeks. This report describes a case of granulomatous colitis in a mixed breed dog, and is the first published description of the cytologic features of this uncommon disease, offering a valuable cytologic-histologic correlation. In this case, the cytology was helpful in identifying features consistent with granulomatous colitis and prioritizing the differential diagnoses and diagnostic plan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34664295/