Peer-reviewed veterinary case report
Correlation of cytology to histology in a case of canine granulomatous colitis in a Boxer dog.
- Journal:
- Veterinary clinical pathology
- Year:
- 2021
- Authors:
- C. Sims et al.
- Species:
- dog
Plain-English summary
A 2-year-old male mixed breed dog was taken to the veterinary hospital because he had been experiencing chronic diarrhea, blood in his stool, and weight loss. Tests on a sample from his rectum showed certain types of immune cells that suggested he might have an infection. Further examination of tissue confirmed he had granulomatous colitis, which is inflammation of the colon often linked to bacteria, specifically a type called Escherichia coli. He was treated with an antibiotic called enrofloxacin, and after about six weeks, he showed nearly complete improvement in his symptoms. Overall, the treatment was successful.
Abstract
A 2-year-old castrated male mixed breed dog presented to the North Carolina State Veterinary Teaching Hospital for chronic diarrhea with hematochezia and weight loss. Cytology performed on a rectal scraping revealed macrophages containing magenta, light pink, and variably blue granular inclusions, and phagocytosed material concerning for infectious organisms. Histopathology was consistent with granulomatous colitis and identified intra-histiocytic bacterial organisms, confirmed by fluorescent in situ hybridization (FISH)-tissue culture-confirmed Escherichia coli. Based on these findings, a diagnosis of granulomatous colitis was made. The patient was successfully treated with oral enrofloxacin, and near-complete remission of signs was achieved within 6 weeks. This report describes a case of granulomatous colitis in a mixed breed dog, and is the first published description of the cytologic features of this uncommon disease, offering a valuable cytologic-histologic correlation. In this case, the cytology was helpful in identifying features consistent with granulomatous colitis and prioritizing the differential diagnoses and diagnostic plan.
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Search related cases →Original publication: https://www.semanticscholar.org/paper/34664295