Peer-reviewed veterinary case report
Correlation of expression of STAT3, VEGF and differentiation of Th17 cells in psoriasis vulgaris of guinea pig.
- Journal:
- Asian Pacific journal of tropical medicine
- Year:
- 2014
- Authors:
- Zheng, Xiu-Fen et al.
- Affiliation:
- Department of Dermatology · China
- Species:
- rodent
Abstract
OBJECTIVE: To investigate the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis. METHODS: A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected. The ratio of Th17/ IL-17 cell in peripheral blood were detected by flow cytometric analysis; STAT3 and VEGF concentrations were measured by immunohistochemistry and Western blot. RESULTS: The expression of Th17 in peripheral blood were significantly increased in psoriasis [(1.76±0.88)%] compared with controls [(0.48±0.27)%] (P<0.05). Th17 related cytokine STAT3 and VEGF were significantly increased in psoriasis compared with controls (P<0.05), and were positively correlated the expression of Th17. CONCLUSIONS: The expressions of Th17, STAT3 and VEGF are elevated in psoriasis, which suggests Th17 cells have a potential role in the pathogenesis of psoriasis by STAT3-VEGF pathway.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24507689/