Peer-reviewed veterinary case report
Mast cell patterns in lymph nodes linked to dog tumor outcomes
By Weishaar, K M et al.·Published in Journal of comparative pathology·2014·Department of Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors (a type of skin cancer) was studied to see how the presence of mast cells in their lymph nodes affected their health outcomes. Researchers found that different patterns of these mast cells could help predict how well the dogs would do after treatment. They proposed a new classification system to better evaluate the severity of the disease based on the lymph nodes' condition. This information can help veterinarians determine the best treatment options and give pet owners a clearer idea of what to expect for their dogs' health.
People also search for: dog mast cell tumor prognosis · lymph node cancer in dogs · mast cell tumor treatment options
Abstract
Lymph node metastasis in dogs with mast cell tumour has been reported as a negative prognostic indicator; however, no standardized histological criteria exist to define metastatic disease. The primary aim of this study was to determine whether different histological patterns of node-associated mast cells correlate with clinical outcome in dogs with mast cell tumour. A secondary goal was to propose a criteria-defined classification system for histological evaluation of lymph node metastasis. The Colorado State University Diagnostic Medicine Center database was searched for cases of canine mast cell tumours with reported lymph node metastasis or evidence of node-associated mast cells. Additional cases were obtained from a clinical trial involving sentinel lymph node mapping and node extirpation in dogs with mast cell neoplasia. Forty-one cases were identified for inclusion in the study. Demographic data, treatment and clinical outcome were collected for each case. Lymph nodes were classified according to a novel classification system (HN0-HN3) based on the number of, distribution of, and architectural disruption by, nodal mast cells. The findings of this study indicate that characterization of nodal mast cells as proposed by this novel classification system correlates with, and is prognostic for, clinical outcome in dogs with mast cell tumours.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25172053/