Peer-reviewed veterinary case report
Blood markers linked to heart valve disease stages in dogs
By Polizopoulou, Zoe S et al.·Published in Veterinary clinical pathology·2015·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Correlation of serum cardiac troponin I and acute phase protein concentrations with clinical staging in dogs with degenerative mitral valve disease.
- Species:
- dog
Plain-English summary
A group of dogs with degenerative mitral valve disease (MVD) showed varying levels of heart injury and inflammation based on their symptoms. The study measured specific proteins in their blood to see how they related to the severity of the disease. Dogs with more advanced heart failure had higher levels of certain inflammatory markers, while those with milder symptoms had lower levels. Over a six-month period, the levels of these markers changed, indicating that monitoring them could help assess the condition of dogs with MVD. This information can help veterinarians tailor treatment plans for affected dogs.
People also search for: dog heart disease symptoms · degenerative mitral valve disease treatment · dog heart failure inflammation markers
Abstract
BACKGROUND: Cardiac troponin I (cTnI) correlates with severity of myocardial injury. Nonspecific inflammation in congestive heart failure (CHF) could be assessed by C-reactive protein (CRP), haptoglobin (Hp), and ceruloplasmin (Cp) measurements. OBJECTIVES: The aim of the study was to determine whether serum cTnI, CRP, Hp, and Cp concentrations differ among various stages of mitral valve disease (MVD) in dogs. MATERIALS AND METHODS: Dogs with MVD were allocated to 3 groups (I - asymptomatic; II - mild to moderate CHF; III advanced CHF) according to the scheme of the International Small Animal Cardiac Healthy Council (ISACHC). Concentrations of cTnI, CRP, Cp, and Hp were measured in all dogs upon admission, and cTnI and CRP were measured bimonthly during a 4-month follow-up period. RESULTS: In total 46 dogs with MVD were enrolled for the cross-sectional part (21 Group I, 11 Group II, 14 Group III), and 35 dogs were included in the longitudinal study. Initial mean Cp concentrations were similar among all groups. There was a statistically significant difference in Hp and CRP concentrations between group I (n = 21, P = .019) and III (n = 14, P < .001). There was a statistically significant decrease in CRP (P = .033) and cTnI (P = .009) concentrations over the longitudinal study (all groups). CRP concentrations were significantly higher in group I than III (P = .004). During the 6-month monitoring period of 35 dogs, there was a statistically significant positive correlation between cTnI and CRP (P < .001). CONCLUSION: Differences in CRP concentrations between clinical stages of MVD suggest a clinically and therapeutically relevant inflammatory component.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26288324/