Peer-reviewed veterinary case report
Serum chloride levels linked to hormone changes in dog with heart
By Banken, Cailey et al.·Published in Journal of veterinary internal medicine·2024·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.
- Species:
- dog
Plain-English summary
A 7-year-old male Cavalier King Charles Spaniel was hospitalized for 12 days due to severe congestive heart failure caused by a heart valve issue. During his stay, the vet monitored his blood samples to check various substances related to heart function. They found that low levels of chloride in his blood were linked to other markers that indicate heart problems. This suggests that low chloride levels could be a sign of worsening heart failure in dogs. The dog received treatment for his heart condition, but the study highlights the need for further research into how these blood levels affect heart health.
People also search for: dog congestive heart failure treatment · Cavalier King Charles Spaniel heart problems · low chloride levels in dogs
Abstract
A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39482042/