Peer-reviewed veterinary case report
Corticoid levels in dogs with adrenal tumors during mitotane treatment
By Rijnberk, A et al.·Published in The Veterinary record·1992·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Corticoid production by four dogs with hyperfunctioning adrenocortical tumours during treatment with mitotane (o,p'-DDD).
- Species:
- dog
Plain-English summary
Two dogs with high cortisol levels due to adrenal tumors were treated with a medication called o,p'-DDD. One dog did not respond well and needed additional corticosteroid supplements, while the other showed a significant decrease in cortisol levels after just six days of treatment. Two more dogs were treated with a different approach that aimed to completely destroy the adrenal glands, and both recovered well, with their cortisol levels returning to normal. One of these dogs even had a noticeable reduction in tumor size within five weeks of starting treatment.
People also search for: dog adrenal tumor treatment · high cortisol levels in dogs · o · p'-DDD for dog hyperadrenocorticism
Abstract
In two dogs with hyperadrenocorticism due to an adrenocortical tumour, treatment with o,p'-DDD was started. Their hormonal response was monitored by measurements of the urinary corticoid/creatinine ratio. In one dog, two courses of 10 days treatment with o,p'-DDD were ineffective, whereas in the other dog the urinary corticoids decreased to very low levels after only six days of treatment, and corticosteroid supplementation had to be started. Two other dogs received o,p'-DDD according to a protocol used for the treatment of pituitary-dependent hyperadrenocorticism which aims at the complete destruction of the adrenal cortices, with substitution for the induced hyperadrenocorticism. Both dogs made a good recovery and their urinary corticoid/creatinine ratio decreased to within the reference range. In one of them the tumour had decreased considerably in size by five weeks after the start of the treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1471327/