Peer-reviewed veterinary case report
Cortisol levels in dogs well controlled on trilostane for Cushing's
By Midence, J N et al.·Published in Journal of veterinary internal medicine·2015·Department of Clinical Studies - Philadelphia, United States·View original on PubMed →
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Original publication title: Cortisol Concentrations in Well-Regulated Dogs with Hyperadrenocorticism Treated with Trilostane.
- Species:
- dog
Plain-English summary
A group of 13 dogs with well-managed hyperadrenocorticism (a condition causing high cortisol levels) were tested to see how their cortisol levels changed after receiving a medication called trilostane. The dogs had low cortisol levels before and after an initial stimulation test, but when tested again 9-12 hours later, their cortisol levels were significantly higher. This suggests that even in well-regulated dogs, cortisol levels can vary throughout the day, which may help veterinarians decide on continuing trilostane treatment.
People also search for: dog hyperadrenocorticism treatment · trilostane for dogs · cortisol levels in dogs
Abstract
BACKGROUND: There are no clear treatment guidelines for dogs with clinically well-regulated hyperadrenocorticism in which serum cortisol concentrations before and after an ACTH stimulation test performed 3-6 hours after trilostane administration are < 2.0 μg/dL. OBJECTIVE: To determine if serum cortisol concentrations measured before (Pre1) and after (Post1) ACTH stimulation at 3-6 hours after trilostane administration are significantly lower than cortisol concentrations measured before (Pre2) and after (Post2) ACTH stimulation 9-12 hours after trilostane administration, in a specific population of dogs with clinically well-regulated hyperadrenocorticism and Pre1 and Post1 <2 μg/dL. ANIMALS: Thirteen client-owned dogs with clinically well-regulated hyperadrenocorticism and Pre1 and Post1 serum cortisol concentrations <2.0 μg/dL 3-6 hours after trilostane administration. METHODS: Prospective study. Dogs had a second ACTH stimulation test performed 9-12 hours after trilostane administration, on the same day of the first ACTH stimulation test. Cortisol concentrations before and after ACTH stimulation were compared using a paired t-test. RESULTS: Cortisol concentrations before (1.4 ± 0.3 μg/dL) and after the first stimulation (1.5 ± 0.3 μg/dL, mean ± SD) were significantly lower than cortisol concentration before the second stimulation (3.3 ± 1.6 μg/dL, P = .0012 each). Cortisol concentration before the first stimulation was also significantly lower than cortisol concentration after the second stimulation (5.3 ± 2.4 μg/dL, P = .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: In dogs with clinically well-regulated, trilostane-treated, hyperadrenocorticism, and cortisol concentrations <2 μg/dL before and after the first stimulation, a second ACTH stimulation test performed 9-12 hours after treatment can result in higher cortisol concentrations that could support continued trilostane treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26374943/