Peer-reviewed veterinary case report
How ragweed allergy affects cough reflex in dogs
By House, Aileen et al.·Published in European journal of pharmacology·2004·Schering-Plough Research Institute, United States·View original on PubMed →
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Original publication title: Cough reflex in allergic dogs.
- Species:
- dog
Plain-English summary
A group of dogs with allergies to ragweed were tested to see how their cough reflex responded to exposure. When these dogs were exposed to ragweed, they didn't cough spontaneously, but their breathing rate increased and their lung function decreased. However, when their trachea was stimulated, they coughed more often, though the strength of those coughs was weaker compared to when they were given saline. Thankfully, their cough response returned to normal within 24 to 48 hours after the exposure.
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Abstract
This study investigated the effects of antigen challenge on the cough reflex in dogs that were neonatally sensitized to ragweed. Tidal volume (V(T)), respiratory rate (f), pulmonary resistance (R(L)), dynamic lung compliance (C(Dyn)) and the number and amplitude (increase in mean peak expiratory pressure) of coughs induced by mechanical stimulation of the intrathoracic trachea were measured in propofol-anesthetized dogs. Aerosolized ragweed challenge had no effect to induce spontaneous cough but increased f and R(L) and reduced V(T) and C(Dyn). Mechanical stimulation of the intrathoracic trachea at this time produced 19+/-5 coughs with an average increase in cough amplitude of 11+/-1 cm H(2)O which differed significantly from the number (9+/-2 coughs) and amplitude (30+/-5.5 cm H(2)O) of mechanically induced coughs after treatment with aerosolized saline. Both the number and amplitude of mechanically induced coughs returned to baseline values by 24-48 h after the ragweed challenge. Similar results were obtained after challenge with aerosolized histamine (0.3-1% histamine) that did not induce spontaneous coughs but increased f, reduced V(T) and decreased C(Dyn) and increased the number but reduced the amplitude of the mechanically induced coughs. In conclusion, both antigen and histamine bronchoprovocation changed the characteristics of the mechanically induced cough in dogs to a response of increased cough number but reduced mean expiratory cough amplitude.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15178372/