Peer-reviewed veterinary case report
Coupling of ORL1 (NOP) receptor to G proteins is decreased in the nucleus accumbens of anxious relative to non-anxious mice.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Le Maître, Erwan et al.
- Affiliation:
- Unité · France
- Species:
- rodent
Abstract
We studied the involvement of endogenous ORL1 (NOP) receptors in the anxiety state. In mice selected as "anxious" and "non-anxious", ORL1 (NOP) receptor has been analysed by means of two autoradiographic approaches: [3H]nociceptin binding and nociceptin-stimulated [35S]GTPgammaS binding. We show that differences in anxiety state are associated with differences in G protein coupling efficiency of ORL1 (NOP) receptor in the nucleus accumbens, without any change in the density of the receptors.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16860781/