Peer-reviewed veterinary case report
CpG motif in ATCGAT hexamer improves DNA-vaccine efficiency against lethal Pseudorabies virus infection in pigs.
- Journal:
- Vaccine
- Year:
- 2005
- Authors:
- Dory, Daniel et al.
- Affiliation:
- Viral Genetics and Biosafety Unit · France
Abstract
This study evaluated the adjuvant activity of a porcine-specific type A CpG-containing oligodeoxynucleotide (CpG-ODN) in a DNA-vaccine against Pseudorabies virus (PrV) infection. This vaccine, composed of three independent plasmids encoding PrV gB, gC and gD glycoproteins, was injected alone or was co-injected with CpG-ODN or control GpC-ODN. CpG-ODN improved the PrV-specific humoral immune response and provided better clinical protection against lethal PrV-infection. The PrV-specific cell-mediated immune response seemed also to be increased.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15921828/