Peer-reviewed veterinary case report
Kidney function tests in cats with caudal stomatitis compared
By Vetter, C Autumn M et al.·Published in Journal of feline medicine and surgery·2023·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Cross-sectional characterization of renal function in cats with caudal stomatitis.
- Species:
- cat
Plain-English summary
A group of cats with caudal stomatitis (a painful inflammation of the mouth) was studied to see if they had any kidney problems compared to healthy cats of the same age. The researchers measured various kidney function markers and found that the cats with stomatitis had lower levels of certain substances like serum creatinine and albumin, but they also had higher levels of phosphorus and potassium. However, there were no significant differences in kidney disease rates between the two groups. This suggests that having caudal stomatitis does not necessarily mean a cat will have kidney disease, but more research is needed to explore this further.
People also search for: cat kidney disease symptoms · caudal stomatitis treatment in cats · cat mouth inflammation and kidney health
Abstract
OBJECTIVES: The objective of the study was to compare renal functional biomarkers in cats and in caudal stomatitis (CS) and in age-matched control cats. METHODS: A cross-sectional, case-control study was conducted on 44 client-owned cats with CS that were prospectively enrolled and evaluated for a Comprehensive Oral Health Assessment and Treatment at one of four institutions. Renal function was assessed with measurement of serum creatinine, urea nitrogen, serum symmetric dimethylarginine, urinalysis, urine protein:creatinine ratio and urine protein electrophoresis. Affected gingiva was biopsied to confirm the diagnosis of stomatitis. Renal biochemical analyses from the experimental group were compared with those of 44 age-matched controls without CS enrolled prospectively or retrospectively after presenting to the primary institution for routine healthcare. Control cats were included if they were clinically stable, their chronic illnesses were well managed and minimal dental disease was present on examination. Renal biomarkers were compared between groups using a-test or the Mann-Whitney U-test. Frequency of azotemia, proteinuria and the clinical diagnosis of renal disease were compared using Fisher's exact test. RESULTS: Relative to the control group, cats in the CS group had significantly lower serum creatinine (<0.001) and albumin concentrations (<0.001), urine specific gravity ( = 0.024) and hematocrit ( = 0.003), and higher serum phosphorus (<0.001), potassium (<0.001) and globulin concentrations (<0.001), white blood cell count (<0.001) and urine protein:creatinine ratio ( = 0.009). There were no significant differences in serum symmetric dimethylarginine or urea nitrogen concentrations. No clinically significant findings were noted on urine protein electrophoresis. There were no significant differences in the frequency of azotemia, proteinuria or renal disease categories between the two groups. CONCLUSIONS AND RELEVANCE: The present study does not demonstrate a significant difference in the frequency of kidney disease between cats with and without CS. Longitudinal evaluation is warranted to investigate the relationship between renal disease and CS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37350300/