Peer-reviewed veterinary case report
Cultivation, LD(50) determination and experimental model of Streptococcus suis serotype 2 strain HA9801.
- Journal:
- Research in veterinary science
- Year:
- 2009
- Authors:
- Zhao, Zhanzhong et al.
- Affiliation:
- Department of Pharmacy · China
Abstract
The effects of nutritional components and submerged culture conditions on colony-forming unit (CFU) counts by Streptococcus suis serotype 2 strain HA9801 in flask culture was investigated, and the optimal medium and cultivation conditions was confirmed by using a 50l bioreactor. The LD(50) values of HA9801 in pigs before and after fermentation were 1.8 x 10(7)CFU, which indicated that the virulence of HA9801 was very stable in the fermentation process. In addition, an experimental model that closely mimics naturally occurring disease in conventional pigs was established.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18774148/