Current Challenges in Hemostasis and Advances in Particle-Assisted Styptic Devices.

Abstract

Rapid and effective hemorrhage control is critical in trauma and surgical interventions, where uncontrolled bleeding remains a leading cause of preventable death. In response to this urgent clinical demand, the development of novel hemostatic materials is the focus of increasing research interest, in both academia and industry. Styptic dressings are gradually evolving to address this need. However, significant challenges, such as delayed activation, suboptimal performance in severe conditions, and biocompatibility issues, persist. Here current limitations in hemostatic dressing technologies are explored, and recent innovations including biomimetic approaches in this field are highlighted. Special emphasis is placed on microparticle-integrated and nanoengineered systems integrated with drug delivery technologies. By addressing these challenges, it is aimed to inspire new pathways for the development of next-generation multifunctional dressings with enhanced efficacy and accessibility.