Peer-reviewed veterinary case report
Dog with rare skin cancer showing granular cell features
By Bolfa, Pompei et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Ross University School of Veterinary Medicine·View original on PubMed →
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Original publication title: Cutaneous epithelioid hemangiosarcoma with granular cell differentiation in a dog: a case report and review of the literature.
- Species:
- dog
Plain-English summary
A 10-year-old female mixed-breed dog was diagnosed with cutaneous epithelioid hemangiosarcoma, a type of skin cancer that showed features similar to granular cell tumors. The dog had a tumor on its skin, and the diagnosis was confirmed through specific tests that looked at the tumor's cells. Treatment options were not detailed in the study, but typically, surgery to remove the tumor and possibly additional therapies would be considered for this type of cancer. Early detection and appropriate treatment are crucial for the best outcome in cases like this.
People also search for: dog skin cancer treatment · hemangiosarcoma in dogs · granular cell tumor in dogs
Abstract
We report a case of cutaneous epithelioid hemangiosarcoma in a dog in which the majority of the neoplastic cells displayed histologic and ultrastructural features similar to those seen in granular cell tumors (GCTs). This intersection of hemangiosarcoma and granular cell change adds to the argument that GCTs are heterogeneous in histologic origin and underlines the fact that pathologists should not consider all GCTs as a single entity. The combination of histology in typical areas of the tumor with ultrastructural changes and the correct immunohistochemical markers can facilitate the accurate diagnosis of tumors with granular cell differentiation. Besides characteristic intracytoplasmic PAS-positive granules and ultrastructural proteinaceous accumulation within single membrane vesicles (presumably lysosomes and phagolysosomes), we suggest the following combination of markers for the diagnosis of granular cell angiosarcoma and/or hemangiosarcoma: vimentin positive, NSE and/or S100 negative, CD31 positive. We propose that the histologic granular appearance represents a metabolic defect of the neoplastic cells, which supports variability in cell origin for granular cell differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30136913/