Peer-reviewed veterinary case report
Skin cancer tumor with E-cadherin in Pembroke Welsh Corgi dog
By Hirako, Ayano et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2015·Department of Veterinary Laboratory Medicine (Hirako, United States·View original on PubMed →
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Original publication title: Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog.
- Species:
- dog
Plain-English summary
An 11-year-old male neutered Pembroke Welsh Corgi was brought to the vet with a large skin mass measuring about 7.5 cm by 6.6 cm. The mass was found to be a type of cancer called cutaneous histiocytic sarcoma, which means it was made up of abnormal cells growing in the skin. The tumor was aggressive, showing signs of invasion into surrounding tissues. Unfortunately, this specific type of cancer is rare in dogs, and the treatment options can vary. The outcome for this dog would depend on the treatment chosen by the veterinarian, which may include surgery or other therapies.
People also search for: Pembroke Welsh Corgi skin mass · dog skin cancer treatment · cutaneous histiocytic sarcoma in dogs
Abstract
An 11-year-old male neutered Pembroke Welsh Corgi dog displayed a mass measuring 7.5 cm × 6.6 cm × 1.6 cm in the skin. Neoplastic tissue was nonencapsulated, and the neoplastic cells showed infiltrative growth into the surrounding tissue on microscopic examination. The neoplastic tissue was mainly located from the dermis to the subcutis. Epidermotropism of neoplastic cells was not observed. The tissue was composed of irregular, solid nests of round to polygonal cells. Nests were separated by fine fibrovascular stroma. Mitotic index was high (7.90 ± 0.38 per high power field) and extensive necrosis was observed in the neoplastic tissue. Vascular invasion was often observed in the neoplastic tissue. Neoplastic cells were positive for vimentin, HLA-DR antigen, Iba1, CD18, and E-cadherin, but cells did not express cytokeratin, S100, CD20, CD79α, CD3, MUM-1, lambda light chain, kappa light chain, lysozyme, CD204, or CD11d by immunohistochemistry. Electron microscopic analysis revealed dendrites on these cells. From the above-mentioned findings, the tumor was diagnosed as a cutaneous histiocytic sarcoma with E-cadherin expression. It is possible that neoplastic cells in the present case were derived from cutaneous Langerhans cell. To our knowledge, cutaneous histiocytic sarcoma with E-cadherin expression in domestic animals has not been previously diagnosed in domestic animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26330395/