Peer-reviewed veterinary case report
Cutaneous mastocytosis causing itchy skin lumps in young dogs
By Yang, Ching et al.·Published in Veterinary pathology·2023·University of Pennsylvania, United States·View original on PubMed →
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Original publication title: Cutaneous mastocytosis in 8 young dogs and review of literature.
- Species:
- dog
Plain-English summary
An 8-month-old Labrador was diagnosed with cutaneous mastocytosis, a rare skin condition that caused multiple lumps and bumps all over his body. The dog had over 50 lesions and was often itchy. Treatment included antihistamines and corticosteroids, which helped manage his symptoms. While six of the eight dogs in the study were still alive after nearly three years, two were euthanized due to complications related to their condition. This highlights the importance of monitoring and treating skin issues in young dogs.
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Abstract
Cutaneous mastocytosis (CM) is a rare condition in young dogs characterized by multicentric cutaneous proliferation of neoplastic mast cells. Clinical data from 8 dogs that met inclusion criteria (age of onset less than 1.5 years, greater than 3 lesions) were obtained via a standardized survey. Biopsy samples were classified by the Kiupel/Patnaik grading systems and analyzed formutations. The median age of onset was 6 months (range: 2-17 months). Dogs had 5 to more than 50 lesions characterized as nodules, plaques, and papules. Seven dogs were pruritic. Clinical staging in 2 dogs did not reveal visceral involvement. No dogs had systemic illnesses at diagnosis. Histologically, CM was similar to cutaneous mast cell tumor (cMCT). Two dogs had neoplasms classified as high-grade/grade II while 6 dogs had low-grade/grade II neoplasms. No dogs had mutations inexons 8 and 11. Treatment included antihistamines (8/8), corticosteroids (7/8), lokivetmab (3/8), and toceranib (1/8). Six dogs were alive with lesions at the end of the study with a median follow-up time of 898 days, while 2 dogs were euthanized. In dogs with high-grade/grade II neoplasms, one continued to develop lesions at 1922 days post-diagnosis, while the other dog was euthanized at 56 days post-diagnosis. One dog was euthanized 621 days post-diagnosis due to rupture of a neoplasm. CM occurs in young dogs and is histologically indistinguishable from cMCT. Current histologic grading systems did not apply uniformly to the dogs of the study and further studies are needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37222130/