Peer-reviewed veterinary case report
Skin Nocardia infection in dogs treated with ciclosporin for atopic
By Siak, Meng K. & Burrows, Amanda K.·Published in Veterinary Dermatology·2013·Animal Dermatology Clinic‐Perth School of Veterinary and Biomedical Science Murdoch Veterinary Hospital Murdoch University Murdoch WA 6150 Australia, Australia·View original on Crossref →
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Original publication title: Cutaneous nocardiosis in two dogs receiving ciclosporin therapy for the management of canine atopic dermatitis
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog developed skin infections after being treated with ciclosporin for atopic dermatitis (a skin allergy). Another dog, a 7-year-old Labrador, also had a skin infection while on ciclosporin, and its medication levels were found to be higher than normal due to a combination with ketoconazole, an antifungal. Both dogs were diagnosed with nocardiosis, a rare infection caused by Nocardia bacteria. The veterinarians emphasized the importance of monitoring ciclosporin levels to prevent such infections in dogs receiving this treatment.
People also search for: dog skin infection ciclosporin · atopic dermatitis treatment dog · Nocardia infection in dogs
Abstract
BackgroundCiclosporin is a calcineurin inhibitor that is currently registered for the treatment of canine atopic dermatitis. The most common adverse effects include mild, transient gastrointestinal disturbances. Single case reports of opportunistic infections due to Nocardia spp., Neospora spp. and papillomaviruses have also been reported.Hypothesis/ObjectivesClinicians should be aware of the potential risk of systemic immunosuppression and subsequent infection with Nocardia spp. in dogs receiving ciclosporin.AnimalsCutaneous nocardiosis in two dogs receiving ciclosporin therapy for management of canine atopic dermatitis.MethodsHistopathology, PCR for Nocardia spp. and computed tomography.ResultsOne dog developed disseminated nocardiosis due to Nocardia brasiliensis and a second dog developed localized cutaneous nocardiosis due to a novel Nocardia species subsequent to ciclosporin administration at the recommended dose rate for the management of canine atopic dermatitis. The second case was receiving a combination of ciclosporin and ketoconazole, and serum trough ciclosporin levels were elevated.Conclusions and clinical importanceClinicians should be aware of the potential risk of systemic immunosuppression and subsequent infection with Nocardia spp. in dogs receiving ciclosporin. Measurement of serum ciclosporin levels may be useful in identifying those individuals which are at risk of opportunistic infections.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.12046