Peer-reviewed veterinary case report
Rare skin plasmacytosis in two dogs with different outcomes
By Inai, Kiyohiko et al.·Published in The Journal of veterinary medical science·2026·VCA Japan Sakura Animal Hospital, Japan·View original on PubMed →
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Original publication title: Cutaneous plasmacytosis with atypical clinical behavior in two dogs.
- Species:
- dog
Plain-English summary
A 6-year-old female mixed-breed dog was brought in with multiple skin nodules on her face and limbs, along with worsening itching. Despite being diagnosed with cutaneous plasmacytosis (a rare skin condition) and treated with medications like prednisolone and melphalan, she unfortunately passed away about five months later. In another case, a 5-year-old male Labrador had similar skin nodules on his back and abdomen, but surprisingly, these nodules started to shrink on their own within four weeks without any treatment. These cases highlight that cutaneous plasmacytosis can behave differently in dogs, which can help veterinarians understand this condition better.
People also search for: dog skin nodules treatment · why is my dog itching · cutaneous plasmacytosis in dogs · dog skin problems · mixed-breed dog skin lumps
Abstract
Cutaneous plasmacytosis (CP) is a rare condition characterized by multiple cutaneous plasmacytomas without multiple myeloma. While no pruritus or spontaneous regression occurs in typical CP, the clinical behavior is limitedly understood due to its low incidence. This case report describes atypical cases of CP. Case 1 had skin nodules on the face and limbs and pruritus, whose pruritus kept progressing. After the diagnosis of CP, the dog died on Day 170 despite the treatment with prednisolone and melphalan since Day 157. Case 2 had multiple skin nodules on the back and abdomen. After the skin biopsy, the nodules regressed without treatment on Day 28. These cases suggest the variation of CP's clinical behavior, which helps further understand the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41581902/