Peer-reviewed veterinary case report
CXCR3 blockade: a novel anti-sepsis approach?
- Journal:
- Critical care (London, England)
- Year:
- 2012
- Authors:
- Delano, Matthew J & Moldawer, Lyle L
Abstract
Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23171733/