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Peer-reviewed veterinary case report

Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration.

Journal:
Veterinary ophthalmology
Year:
2002
Authors:
Bromberg, Nancy M
Affiliation:
Eye Clinic for Animals · United States

Plain-English summary

In this study, researchers used a special glue called isobutyl cyanoacrylate tissue adhesive to treat stubborn corneal ulcers (sores on the eye surface) in 17 dogs, one cat, and one rabbit. These ulcers had been present for 2 weeks to 7 months, with an average of about 7 weeks. Most pets only needed a little sedation, just a numbing drop before the treatment. After the glue was applied, pets experienced some mild discomfort for a few days, but the ulcers healed within about 3 weeks, and any related eye issues were treated with eye drops. Overall, this method proved to be a simple, safe, and effective way to treat these difficult eye problems.

Abstract

Isobutyl cyanoacrylate tissue adhesive (BCTA) was used in the treatment of refractory superficial corneal ulcers in 17 dogs, one cat, and one rabbit, present 2 weeks to 7 months (mean 6.8 weeks +/- 6.1) prior to referral. Little to no sedation was required in the majority of cases, with only topical anesthetic applied prior to debridement and BCTA application. The presence of the tissue adhesive caused mild discomfort for several days after application, as reported by the owners. The ulcers healed, and the tissue adhesive sloughed in approximately 3 weeks (+/- 1 week). Mild neovascularization of the cornea resolved with topical corticosteroids. The use of BCTA offers a simple, safe and noninvasive treatment for refractory corneal ulcers.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/11940249/