Peer-reviewed veterinary case report
COX-2 enzyme found in dog corneas with keratitis inflammation
By Sellers, R S et al.·Published in Veterinary pathology·2004·Pfizer Research and Development, United States·View original on PubMed →
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Original publication title: Cyclooxygenase-2 expression in the cornea of dogs with keratitis.
- Species:
- dog
Plain-English summary
A group of dogs with keratitis, which is an inflammation of the eye, showed increased levels of a protein called COX-2 in their corneas. This protein is linked to inflammation and could be a target for new treatments. In healthy dogs, COX-2 was not present in the cornea, but in dogs with keratitis, it was found in all layers of the cornea and other eye structures. This suggests that medications that inhibit COX-2 might help manage eye inflammation in dogs.
People also search for: dog eye problems keratitis · COX-2 inhibitors for dogs · dog eye inflammation treatment
Abstract
Cyclooxygenase-2 (COX-2) can be overexpressed at inflammatory sites, leading to the generation of proinflammatory prostanoids. Selective inhibitors of COX-2 have potential use in treating inflammatory conditions including ophthalmic diseases in veterinary medicine. Keratitis is considered the most common inflammatory eye disease in dogs. In this study we evaluated the expression of COX-2 in normal dog eyes and in dog eyes with keratitis by immunohistochemistry using isoform-specific antibodies. In the normal eye (n = 4), no COX-2 immunoreactivity was observed in the cornea. In keratitis, COX-2 (n = 12) expression was observed in all corneal layers (epithelium, stromal cells, and endothelium). COX-2 immunoreactivity was also noted in the stromal and epithelial cells of the iris and the stromal cells of the trabecular meshwork. These data indicate that COX-2 may play a pathophysiologic role in keratitis and suggest potential therapeutic implications of prostaglandin modulation in inflammatory eye diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15017024/