Peer-reviewed veterinary case report
Dog with granulomatous sebaceous adenitis treated successfully
By Carothers, M A et al.·Published in Journal of the American Veterinary Medical Association·1991·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Cyclosporine-responsive granulomatous sebaceous adenitis in a dog.
- Species:
- dog
Plain-English summary
A 2-year-old spayed Miniature Pinscher was brought in for skin problems caused by granulomatous sebaceous adenitis, which was affecting her coat and skin health. Initial treatments with isotretinoin and prednisone did not work well and even caused side effects like decreased tear production and temporary diabetes. However, when cyclosporine was given, the dog showed significant improvement in her skin condition for a full year, even though the underlying issue with her sebaceous glands remained. This suggests that cyclosporine can be an effective treatment for this type of skin problem in dogs.
People also search for: Miniature Pinscher skin problems · cyclosporine for dog dermatitis · dog sebaceous adenitis treatment
Abstract
Granulomatous sebaceous adenitis was diagnosed in a 2 year old spayed Miniature Pinscher. Initial treatment with isotretinoin for 3 weeks resulted in little response and decreased tear production. Immunosuppressive doses of prednisone for 3 weeks resulted in mild response of the dermatitis; however, the dog developed transient diabetes mellitus secondary to this treatment. Cyclosporine (5 mg/kg of body weight, po, q 12 h) resulted in good clinical response for 12 months, but histologically, the sebaceous glands remained absent. Although cyclosporine has immunosuppressive properties, this drug also has inhibitory effects of keratinocyte proliferation. These mechanisms may explain the beneficial response of cyclosporine in the treatment of granulomatous sebaceous adenitis in this dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2061184/