Peer-reviewed veterinary case report
Cystosonographic measurements of canine bladder tumours.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2010
- Authors:
- Hume, C et al.
- Affiliation:
- Department of Clinical Studies · United States
- Species:
- dog
Plain-English summary
This study looked at how the size measurements of bladder tumors in dogs can vary depending on who is measuring them and how full the bladder is. Ten dogs with bladder tumors were examined by three different operators, and they found that the measurements could differ quite a bit. This variability was significant enough that it could lead to misclassifying the tumors as either improving or getting worse. The findings suggest that both the person measuring and the bladder's fullness can affect how we understand the size of these tumors. Overall, the study highlights the need for careful consideration when interpreting bladder tumor measurements in dogs.
Abstract
The purpose of this study was to evaluate the variability of cystosonographic bladder tumor measurements with both operator and bladder volume changes. Ten dogs with bladder tumors were included. In each dog, three operators determined tumor dimensions for three different bladder volumes. Intraclass correlation coefficient was used to assess operator reliability. Response Evaluation Criteria in Solid Tumors (RECIST) and greater than or equal to 50% differences in tumor measurements were used as guidelines. Poor to fair correlations between operators were found for the different tumor dimensions (r(I) = 0.4 - 0.7). The percent differences in tumor dimensions with operator and bladder volume changes were significant enough to misclassify the tumors into the categories of partial response (PR) or progressive disease (PD). These results suggest that cystosonographic measurements of bladder tumors are affected by both changes in operator and bladder volume, and the discrepancies are significant enough to change response classification.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20579325/