Cytokine alterations in the spinal cord and serum of male rats following brachial plexus avulsion-induced neuropathic pain.

Abstract

BACKGROUND: This study investigates cytokine alterations in the spinal cord and serum of male rats following brachial plexus avulsion, a severe peripheral nerve injury leading to neuropathic pain. METHODS: Male Sprague-Dawley rats underwent complete C5 to T1 brachial plexus avulsion, which resulted in long-lasting mechanical and cold allodynia. The researchers utilized a Quantibody Rat Cytokine Array to analyze spinal cord segments and serum samples. RESULTS: The analysis revealed significant increases in cytokines such as vascular endothelial growth factor and interleukin-6 within the spinal cord tissue. Additionally, elevated levels of serum cytokines were detected, indicating the presence of systemic inflammation. CONCLUSION: These findings not only enhance our understanding of the role of cytokine signaling in the development of neuropathic pain but also suggest that targeting these signaling pathways may present a viable therapeutic strategy. By modulating cytokine activity, it might be possible to alleviate neuropathic pain in patients suffering from peripheral nerve injuries, offering a new direction for the treatment of such conditions.