Peer-reviewed veterinary case report
Cytokines in canine inflammatory bowel disease.
- Journal:
- Polish journal of veterinary sciences
- Year:
- 2013
- Authors:
- Kołodziejska-Sawerska, A et al.
- Affiliation:
- Department of Clinical Diagnostics
- Species:
- dog
Plain-English summary
Canine inflammatory bowel disease (IBD) is a condition that causes ongoing stomach issues in dogs, but the exact cause is not known. Researchers have been looking into how the immune system, especially certain proteins called cytokines, might play a role in this disease. In studies, they found that dogs with IBD, particularly German Shepherds, had higher levels of some pro-inflammatory cytokines, which are signals that can promote inflammation, compared to healthy dogs. The studies also showed that dogs with a specific type of IBD called lymphocytic-plasmacytic enteritis (LPE) had increased levels of several cytokines. Overall, the findings suggest that certain cytokines are linked to IBD in dogs, but the disease's progression did not seem to change the levels of these cytokines over time.
Abstract
Canine inflammatory bowel disease is a group of chronic enteropathies characterized by persistent or recurring gastric symptoms with an unknown etiology which are related to histopathological changes in the mucosa of the small and large bowel in the form of cellular infiltration in the mucosal lamina propria. Recent years have witnessed a growing number of investigations into the role of the immune system and, in particular, cytokines in the development of IBD. In this article, the expression of pro-inflammatory (IL-1, IL-2, IL-5, IL-6, IL-12, IL-18, IFN-gamma, TNF-alpha) and anti-inflammatory cytokines (IL-4, IL-10) was compared in canine patients with IBD based on clinical presentation, breed, lamina propria cell infiltrate and histopathological grade. Only selected studies confirmed higher mRNA expression levels of cytokines IL-2, IL-4, IL-5, IL-12p40, IFN-gamma, TNF-alpha and TGF-beta in dogs with IBD in comparison with healthy subjects. GSD were strongly represented in most study populations. Dogs with LPE were characterized by elevated levels of IL-1alpha, IL-1beta, IL-2, IL-5, IL-6, IL-12, TNF-alpha, TGF-beta. The present studies of canine patients with LPC revealed the mRNA expression of cytokines IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p35, IL-12p40, IFN-gamma, TNF-alpha, TGF-beta. In the reviewed studies, the progression of IBD was not accompanied by changes in the mRNA express-
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23691593/