Peer-reviewed veterinary case report
Feline herpesvirus and Chlamydophila felis in cats with eye lesions
By Volopich, Sabine et al.·Published in Veterinary ophthalmology·2005·Department for Small Animals and Horses·View original on PubMed →
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Original publication title: Cytologic findings, and feline herpesvirus DNA and Chlamydophila felis antigen detection rates in normal cats and cats with conjunctival and corneal lesions.
- Species:
- cat
Plain-English summary
A group of 36 cats with eye problems, like conjunctivitis and keratitis, were tested for feline herpesvirus (FHV-1) to see if it was causing their symptoms. The tests showed that 39% of the cats with eye issues had FHV-1 DNA, while only 6% of healthy cats tested positive. The virus was most commonly found in cats with epithelial keratitis, a specific type of eye inflammation. Despite the presence of the virus, no significant link was found between FHV-1 and other eye conditions like conjunctivitis or corneal sequestration. The study suggests that FHV-1 is a common cause of certain eye problems in cats, and treatment may focus on managing these viral infections.
People also search for: cat eye problems · feline herpesvirus symptoms · cat conjunctivitis treatment · cat keratitis causes · how to treat cat eye infections
Abstract
Samples were collected from 36 cats with feline herpesvirus (FHV-1)-related ocular disease (conjunctivitis, epithelial or stromal keratitis, or corneal sequestration), and 17 cats without ocular changes. Corneoconjunctival swabs, scrapings and biopsies were tested in various combinations for presence of FHV-1 DNA using single round (sr) polymerase chain reaction (PCR) and nested PCR (nPCR). Additional swabs from the inferior conjunctival fornix were tested by enzyme-linked immunosorbent assay for Chlamydophila felis antigen. Cytologic evaluation was carried out on conjunctival (cats with conjunctivitis) and corneal (cats with keratitis) cytobrush preparations. FHV-1 DNA was detected by PCR in 14 (39%) cats with ocular disease and 1 (6%) of the control group. Agreement between srPCR and nPCR results was significant (P < 0.01). FHV-1 DNA was detected in 3/7 cats with conjunctivitis, 5/6 cats with epithelial keratitis, 3/11 cats with stromal keratitis, and 3/12 cats with corneal sequestration. There was a significant association (P = 0.0027) between viral presence and epithelial keratitis. However, no significant association was found between viral presence and conjunctivitis (P = 0.059), stromal keratitis (P = 0.15), or corneal sequestration (P = 0.18). With respect to FHV-1 DNA detection, intersample agreement was significant (P < 0.03). No sampling technique seemed more likely than another to harvest detectable viral DNA, except for cats with corneal sequestrum in which viral DNA was not detected using corneoconjunctival swabs. FHV-1 DNA was detected in 6/9 samples with intranuclear inclusion bodies and in 6/7 cats with eosinophils on cytologic examination. All samples tested negative for C. felis antigen.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15644097/