Peer-reviewed veterinary case report
Daily oral vitamin B12 keeps Beagles with hereditary deficiency
By Kook, Peter H & Hersberger, Martin·Published in Journal of veterinary internal medicine·2019·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.
- Species:
- dog
Plain-English summary
Three Beagles with a genetic condition called Imerslund-Gräsbeck syndrome, which causes problems absorbing vitamin B12, were given a daily oral supplement of cyanocobalamin (vitamin B12) to see if it would help maintain their health. Over several months, all three dogs remained in excellent health, and their urine tests showed normal levels of a marker for vitamin B12 deficiency. This suggests that the daily oral supplement effectively kept their vitamin B12 levels stable, similar to previous treatments they had received through injections.
People also search for: Beagle vitamin B12 deficiency treatment · Imerslund-Gräsbeck syndrome in dogs · oral cyanocobalamin for dogs
Abstract
BACKGROUND: Efficacy of PO cobalamin (Cbl) supplementation in dogs with hereditary Cbl malabsorption (Imerslund-Gräsbeck syndrome, IGS) is unknown. OBJECTIVES: To evaluate PO Cbl supplementation in Beagles with IGS previously treated parenterally. We hypothesized that 1 mg cyano-Cbl daily PO would maintain clinical and metabolic remission. ANIMALS: Three client-owned Beagles with IGS and 48 healthy control dogs. METHODS: Prospective study. Daily PO cyanocobalamin (cyano-Cbl; 1 mg) supplementation was monitored for 13 (2 dogs) and 8 months (1 dog). Health status was assessed by owner observations. Methylmalonic acid (MMA)-to-creatinine concentrations were measured using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-TMS) method on urine samples collected monthly. Concurrent measurements of serum MMA concentration (n = 7; UPLC-TMS) were available for 1 dog. RESULTS: All dogs remained in excellent health during PO supplementation. Urine MMA remained consistently low in 2 dogs (median, 2.5 mmol/mol creatinine; range, 1.2-9; healthy dogs [n = 30], median, 2.9 mmol/mol creatinine; range, 1.3-76.5). Urine MMA ranged from 38.9-84.9 mmol/mol creatinine during the first 6 months in 1 dog already known to excrete comparable amounts when supplemented parenterally. Brief antibiotic treatment for an unrelated condition after 6 months resulted in low urine MMA (median, 2.8 mmol/mol creatinine; range, 1.9-4.8) for the next 7 months. All concurrent serum MMA concentrations (median, 651 nmol/L; range, 399-919) before and after month 6 were within the established reference interval (393-1476 nmol/L; n = 48). CONCLUSIONS AND CLINICAL IMPORTANCE: One milligram of cyano-Cbl daily PO appears efficacious for maintaining normal clinical status and normal cellular markers of Cbl metabolism in Beagles with IGS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30554416/