Peer-reviewed veterinary case report
Death by microglia.
- Journal:
- The Journal of experimental medicine
- Year:
- 2019
- Authors:
- Kemal, Shahrnaz & Vassar, Robert
- Affiliation:
- Department of Neurology
Abstract
The roles of microglia and ApoE in tauopathies, such as Alzheimer's disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31645368/