Peer-reviewed veterinary case report
Deciphering the role of natural variation in age-related protein homeostasis.
- Journal:
- BMC biology
- Year:
- 2013
- Authors:
- Kaeberlein, Matt
- Affiliation:
- Department of Pathology · United States
Abstract
Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.See research article: http://www.biomedcentral.com/1741-7007/11/100.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24228595/