Peer-reviewed veterinary case report
Body temperature drops after aglepristone abortion treatment
By Corrada, Y et al.·Published in Animal reproduction science·2005·Clinical Department·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Decrease of body temperature after aglepristone treatment in bitches.
Plain-English summary
A group of pregnant dogs (bitches) received a medication called aglepristone to terminate their pregnancies, and researchers monitored their body temperatures during the process. After treatment, the dogs' body temperatures dropped significantly within 24 hours, but this change was not a reliable indicator of whether the pregnancy was ending. Most of the treated dogs had their pregnancies terminated about 4 days after starting the medication, while the control dogs remained pregnant. The study suggests that while body temperature changes occur after aglepristone treatment, they are not useful for tracking the success of the abortion.
People also search for: dog pregnancy termination medication · aglepristone effects on dogs · why is my dog's temperature dropping after treatment
Abstract
Body temperature responses and the timing of abortions were evaluated in pregnant bitches with the anti-progestin aglepristone. Fifteen purebred and crossbred, 25-45 days pregnant, were included in this study and seven untreated bitches at the same stage of pregnancy served as controls. Treated bitches were administered two applications of aglepristone (10 mg/kg SC) 24 h apart for pregnancy termination. Pregnancy termination was confirmed by ultrasonographic assessment. Body temperature was rectally measured three times a day for 6 days beginning 24 h before treatment or pregnancy diagnosis in the treated and control bitches, respectively. Additionally, serum progesterone concentrations were assessed at time points during the study in the treated bitches. Pregnancy was terminated in 14 treated bitches in a mean+/-S.E.M. of 4.3+/-0.7 days after treatment. Control bitches remained pregnant. In the treated bitches, but not in the controls, body temperature significantly decreased 24 h after the beginning of the treatments (P < 0.01) and then gradually returned to pre-treatment values. Correlation between the day of mean minimum body temperature and the day of pregnancy termination was low (0.07; > 0.05). Progesterone did not show significant change throughout the study. Body temperature does not seem to be a suitable variable to clinically monitor the aborting effect of aglepristone. Decrease of body temperature after aglepristone treatment could represent further evidence of its hypothalamic effects.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15911178/