Peer-reviewed veterinary case report
Lower white blood cell death in dogs with pyometra infection
By Sano, Junichi et al.·Published in The Journal of veterinary medical science·2004·Department of Pathobiology, Japan·View original on PubMed →
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Original publication title: Decreased apoptotic polymorphonuclear leukocyte rate in dogs with pyometra.
- Species:
- dog
Plain-English summary
A 5-year-old female dog was diagnosed with pyometra, a serious infection of the uterus that can cause symptoms like lethargy and vomiting. Researchers found that her immune cells, specifically a type of white blood cell called polymorphonuclear neutrophils, were not dying off as they should, which may affect her ability to fight the infection. This study suggests that dogs with pyometra have a lower rate of these immune cells dying compared to healthy dogs. Treatment for pyometra often involves surgery to remove the infected uterus, which can help the dog recover.
People also search for: dog pyometra symptoms · treatment for dog pyometra · why is my dog lethargic and vomiting
Abstract
Polymorphonuclear neutrophil (PMN) apoptosis was examined in three dogs with pyometra by TUNEL assay in a 24-hr incubation period and compared with that in healthy control dogs (n=5). The incidence of apoptotic PMNs in dogs with pyometra was 26.4 +/- 5% and that in healthy dogs was 54.3 +/- 7%. The results indicated that apoptotic PMN rates in dogs with pyometra were significantly lower than those in control dogs (p<0.05), suggesting the prolongation of PMN survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14960824/